In Europe, anecdotal uses of Allspice extract for dyspepsia and as purgative exist., Hussain A, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C. Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation. Zhang Q, Zhao XH, Wang ZJ. Cultures where allspice is often used in food report fewer negative symptoms during menopause. Eugenol could potentially contribute to the anti-inflammatory function associated with Allspice in traditional medicine. It relieves pain, eases stomach upset, and kills bacteria and fungus. Compounds in allspice are also being investigated for use in the treatment of cancer and hypertension and are used in farming, fishing, and livestock. Food Chem Toxicol. Table 1 lists the main well characterized compounds isolated to date from allspice. Recently, there have been intensive researches about the antioxidant properties of natural dietary agents because of the free radical scavenging ability shown by the whole extract of plants and the components out of it. In similar areas where synthetic pesticides are used like the wood protection and plant disease treatments, Allspice essential oils also have been substituted as a natural alternate for pesticides and fungicide 6)., Kamatou GP, Vermaak I, Viljoen AM. Chemoprevention of Prostate Cancer by Allspice Derived Polyphenol: Ericifolin. One important issue about Quercetin is its absorption and metabolism; it was shown that both the glycoside type of Quercetin, i.e. Its spicy, slightly sweet flavor is similar to cloves, nutmeg, and cinnamon. J Med Food. 2009;47:2716–22. Pak J Biol Sci. In Cuban medicine, Allspice along with other herbal mixtures is used to relieve indigestion. Radical-scavenging against 1,1′-diphenyl-2-picrylhydrazyl (DPPH) assays were used to test the anti-oxidant effect of Eugenol and showed promising results 50). It’s available in most supermarkets, as well as specialty spice stores. Pharmacol Res. . Eugenol suppresses cyclooxy-genase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264. Sign Up to Receive Our Free Coroanvirus Newsletter, Becoming a Vegetarian: Foods to Choose From, Add allspice to gingerbread for additional spiciness, Sprinkle ground allspice on roast vegetables, Make jerk chicken in the traditional Jamaican style, with lots of allspice, Add allspice to curries or stews to add heat and depth, Mix allspice with cinnamon, nutmeg, and cloves to make your own pumpkin spice blend, Add allspice to a meat rub to add flavor to roasts. Further, it has been reported that the allspice leaf extract has central nervous system (CNS) depressant effect at the same time. Pak J Biol Sci. The spice is used in North African and Arabic stews, as well. However, few studies have been reported that estimates the type, quantity and potential implication of such a diet in countries that are known to use Allspice extensively. 2011;59:1996–2003. In Caribbean cuisines, Allspice is the most important spice and used extensively, it’s used in Jamaican jerk seasoning, in mole sauces and pickling. Its use includes use to relieve respiratory congestion and assorted odontalgia (toothache). Anti-proliferation as well as apoptosis induction happens in both p53 dependent and independent pathways 64). 2003;87:241–6. And the mechanisms for anti-inflammatory effect of Quercetin lie in down-regulation of NF-KB pathway 58), inhibition of inflammatory cytokines expression 59) and affecting inflammatory gene expression 60). Allspice. Allspice's anesthetic and analgesic properties can help to ease pain and relax muscles. Allspice can be used in many different kinds of recipes. All parts of Pimenta dioica are used in Folk medicine, the kind of medicine developed over centuries by empirical and in often times by anecdotal evidences and other approaches. Table 1. The British Pharmacopeia Codex supposedly still retained pimento water 8). Allspice is the dried fruit of the Pimenta dioica plant. 2012;32:1595–602. It can be used topically as a poultice made from the spice or as an essential oil. Clove and Eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. Motor disorders and impaired electrical power of pallidal EEG improved by Gallic acid in animal model of parkinson’s disease. Sameri MJ, Sarkaki A, Farbood Y, Mansouri SMT. Towards prostate cancer, gallic acid induces ROS-dependent apoptosis in LNCaP cells 70), inhibits invasion of human prostate PC3 cells by modulating MMP-2 and -9 71), induces cell cycle arrest and apoptosis in DU145 cells 72) and is able to decrease tumor growth and micro vessel density in a xenograft model 73). Along with several other plants extracted studied, this might be one of the mechanisms by which herbal extracts used by South American women alleviates menopausal symptoms. Potential Pharmaceutical Products in Allspice (Pimenta dioica). Kim GN, Jang HD. Eating more allspice seems to be a low-risk treatment for menopause symptoms in many women. Due to the limited research, it's too soon to recommend allspice as a treatment for any condition. Also, it is used for headache, to combat stress and depression and to overcome fatigue because of its comforting scent. Boesch-Saadatmandi C, Wagner AE, Wolffram S, Rimbach G. Effect of Quercetin on inflammatory gene expression in mice liver in vivo – role of redox factor 1, miRNA-122 and miRNA-125b. Carson CF, Hammer KA, Riley TV. Phytochemistry. By using Verywell Health, you accept our, Lana Butner, ND, LAc, is a board-certified naturopathic doctor and licensed acupuncturist in private practice in New York City, The Different Types of Essential Oil Diffusers, How to Use Essential Oils for Aromatherapy, Lemongrass Essential Oil Health Benefits, Uses, and Side Effects, The Health Benefits of Myrrh Essential Oil. Besides solid tumors, gallic acid is also reported to be effective in inhibiting growth and inducing apoptosis in lymphoma cells 75) and inhibiting invasion of human melanoma cells 76). 2000;63:749–52. Eugenol, the compound that makes allspice “spicy,” is sometimes used to treat nausea. Due to the relatively large number and content of aromatic and antioxidant compounds present in Allspice, several groups have attempted to isolate and characterize potential anti-tumor agents in Allspice and Pimenta leaves. Laboratory studies suggest methanol extracts from the plant may alter gene expression, boosting estrogen and reducing progesterone levels. In addition, combination with an established chemotherapy drug, gemcitabine yields better growth inhibition effect with apoptosis induction 51). London: Dorling Kindersley; 2002. Health effects of Quercetin: From antioxidant to nutraceutical. Health effects of Quercetin: From antioxidant to nutraceutical. Kalmes M, Hennen J, Blomeke B. Eugenol and isoeugenol as anti-proliferative agents in skin cancer cells. For example, it is known that Quercetin induces apoptosis in many cancer cell lines when treated at 40–50μM or higher concentration 63). Z Naturforsch C. 2007;62:526–36. Jamaica is also the world’s largest producer of allspice and Jamaican allspice is renowned for being of exceptional quality because it contains a higher level of essential oils, which give it more flavor than Allspice grown in other Caribbean islands or in Central America 3). Cathy Wong is a nutritionist and wellness expert. The berries are picked while still green and unripe and are traditionally dried in the sun. How to Use Essential Oils for Aromatherapy. In other countries Allspice is used mostly in baking desserts such as pumpkin pies, banana bread spice cake, bread pudding and gingerbread. Commercial Allspice is also obtained from the fruits of another related species, Pimenta racemosa (Myrtacea, L) mostly found in Central America. It’s native to Central America and the West Indies, but is used around the world in just about every culture’s cuisine. Mem Inst Oswaldo Cruz. Mol Cancer Ther. On HeLa cells (cervical cancer), Eugenol showed selective cytotoxicity compared to normal mammalian cells. Eugenol—From the Remote Maluku Islands to the International Market Place: A Review of a Remarkable and Versatile Molecule. The most important component isolated from Allspice with strong antioxidant activity is Eugenol which composes 60–90% of the essential oil extracted from Allspice berries. Steep a 1/2 teaspoon of ground allspice powder in 1 cup of hot water for 10 minutes and strain. Used in both sweet and savory dishes, allspice is the main ingredient in Jamaican Jerk sauce, used in stews and desserts in the Middle East, and the key flavoring in liquors Chartreuse and Benedictine. 2012;64:610–6. The English renamed it allspice because it has hints of pepper, cloves, cinnamon, nutmeg, and juniper. Protective Mechanism of Quercetin and Rutin Using Glutathione Metabolism on H 2 O 2 -induced Oxidative Stress in HepG2 Cells. It should be noted however, other than the chemicals isolated from fresh leaves of Pimenta dioica, many of the compounds reported to be in Allspice could potentially be from other known species that produce Allspice, Pimenta racemosa, as commercial Allspice (both berries and powdered form) is a mix of berries from either species. Allspice is also available as an essential oil that can be used aromatically or topically. Thank you, {{}}, for signing up. Clin Microbiol Rev. Briefly, there is limited scope in sequestering the contribution of a single dietary factor for changes in cancer incidence in a population. In vivo quercitrin anti-inflammatory effect involves release of Quercetin, which inhibits inflammation through down-regulation of the NF-κB pathway.

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